Home » Regulation Of Sertoli Cell And Germ Cell Differentiation by R. Brehm
Regulation Of Sertoli Cell And Germ Cell Differentiation R. Brehm

Regulation Of Sertoli Cell And Germ Cell Differentiation

R. Brehm

Published September 16th 2005
ISBN : 9783540257509
Paperback
Enter the sum

 About the Book 

Unwanted childlessness affects approximately one in six couples worldwide. Although the exact proportion of the predominant cause of the problem remains controversial, according to the World Health Organization, in nearly 40 % of cases the cause can be attributed to the female, in 20 % to the male, in 25 % to both, and in 15 % the cause remains unknown. Based on these figures, the incidence of male factor infertility in the general population is approximately 7 %. The majority of these men, approximately 30 %, experience irreversible idiopathic infertility and cannot father children without some form of medical intervention. Male factor infertility, in addition, may be caused by testicular germ cell cancer which is known to represent the most common cancer among young men, aged 15 to 35 years, in Western industrialized countries. The number of affected men has increased dramatically over the past 50 years. There is now growing evidence that human testicular germ cell cancer originates from fetal germ cells exhibiting an aberrant programme of gene expression and tumour progression may be favoured by an aberrant Sertoli cell germ cell communication.